Structural and Biochemical Analysis Reveals the Stereoselectivity of Inhibition and Reactivation of Human Carboxylesterase 1 for the Nerve Agents Sarin, Soman, and Cyclosarin
نویسندگان
چکیده
Departments of Chemistry (M.R.R.) and Biochemistry and Biophysics (A.C.H., C.D.F., M.R.R), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; U.S. Army Medical Research Institute of Chemical Defense (T.C.O., D.M.C.), Aberdeen Proving Ground, Maryland; Human BioMolecular Research Institute (M.M., J.R.C.), San Diego, California; Department of Molecular Pharmacology (M.W., C.C.E., P.M.P.), St. Jude Children’s Research Hospital, Memphis, Tennessee Molecular Pharmacology Fast Forward. Published on January 5, 2010 as doi:10.1124/mol.109.062356
منابع مشابه
Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin.
Organophosphorus (OP) nerve agents are potent toxins that inhibit cholinesterases and produce a rapid and lethal cholinergic crisis. Development of protein-based therapeutics is being pursued with the goal of preventing nerve agent toxicity and protecting against the long-term side effects of these agents. The drug-metabolizing enzyme human carboxylesterase 1 (hCE1) is a candidate protein-based...
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